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Clinical improvements with low-dose IL-2 have been observed in the treatment of systemic lupus erythematosus, rheumatoid arthritis, Behcets disease, ulcerative colitis, and other conditions [81]

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Epidemiological studies highlight a strong association between hyperuricemia/gout and comorbidities such as cardiovascular diseases, chronic kidney disease, and metabolic syndrome, further amplifying their clinical and socioeconomic burden (Nakayama et al., 2023)