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This association was later confirmed in an independent Chinese cohort [101]

Hyperthermia can directly disrupt the structure of biomembranes and the integrity of organelles in primary rat hepatocyte, causing denaturation of intracellular proteins, which is the primary step in the loss of hepatocyte function

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Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM (2006) Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder