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Mao found that treating cancer cells with GPX4 inhibitors resulted in acute depletion of N-carbamyl-L-aspartate (C-ASP, a pyrimidine biosynthesis intermediate), accompanied by accumulation of uridine, which could be inhibited by fer-1, a ferroptosis inhibitor [18]

For this reason, folic acid supplements may mask vitamin-B12-induced megaloblastic anemia and cause an underlying vitamin B12 deficiency to go undetected ( Megaloblastic anemia is a condition characterized by enlarged red blood cells

[DOI] [PubMed] [Google Scholar] 112.Kwan S.T.C., King J.H., Yan J., Jiang X., Wei E., Fomin V.G., Roberson M.S., Caudill M.A

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