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Several studies have indicated that cancer cells cultured under low glucose concentrations or in sugar-free media are more susceptible to the cytotoxic effects of metformin (55,91,99)

However, S -adenosyl-methionine, which, in addition to promoting GSH synthesis, was shown to prevent alterations in membrane lipid composition including cholesterol/phospholipids increase (103, 117), normalizes mGSH levels in alcohol-fed rats by preventing alcohol-induced membrane-fluidity loss (24, 45)

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