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A study showed that in LPS-induced septic skeletal muscle, melatonin preserves mitochondrial function by maintaining the activity of respiratory chain complexes I and IV, restoring ATP production, and stabilizing mitochondrial membrane potential

S 43 then carries out a nucleophilic attack on S 48 , leading to the formation of the redox-active disulfide bridge between Cys 43 and Cys 48 , followed by the cleavage of the covalent bond between S 48 and flavin atom C-4a, producing the reduced FADH anion with a negative charge on atom N-1

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137 Blood Proteins as Antioxidants Human blood proteins are vulnerable to oxidative damage because free radicals can cause alterations in the electrical charge of proteins, induce cross-linking of proteins, and increase their susceptibility to proteolysis

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