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10.1016/j.jmb.2009.09.062 36 DeribeY

ROS-induced damage to DNA, proteins, and lipids can directly lead to cell death, but it also promotes microglial activation and the release of pro-inflammatory cytokines, further exacerbating neurodegeneration (Tfilin et al., 2023)

However, when interpreting founder haplotype effects at QTL ( e.g

Oxidative Stress Markers and Thyroid Autoimmunity Oxidative stressmeasured by malondialdehyde (MDA), 8-OHdG, and reactive oxygen speciesis elevated in Hashimoto's thyroiditis relative to euthyroid controls

In cardiovascular diseases, antioxidants can help reduce oxidative stress and improve endothelial function, thus potentially preventing atherosclerosis and other heart-related issues [198]