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Outside the CNS, serotonin is produced in the ENS and released predominantly by enterochromaffin cells (estimated to be up to 90% of the body's serotonin production [169]) of the gut mucosa and immune cells, with influence not only on the ENS but also on the CNS via the GBA [283]

Platinum-based drugs: cisplatin/Platinol, oxaliplatin/Eloxatin, carboplatin/Paraplatin Taxanes: paclitaxel/Taxol, docetaxel/Taxotere, cabazitaxel/Jevtana Thalidomide and its relatives: carfilzomib/Kyprolis, lenalidomide/Revlimid, pomalidomide/Pomalyst, apremilast/Otezla Epothilones: ixabepilone/Ixempra Proteasome inhibitor: bortezomib/Velcade Vinca alkaloids: vincristine/Marqibo, vinblastine/Velbane The neuropathy caused by most of these drugs commonly shows up weeks or months after treatment has ended

Additionally, MRP2 contains a 100-residue long linker between NBD1 and TMD2, resembling the regulatory (R) domain of the cystic fibrosis transmembrane regulator (CFTR)

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The sequence variability is uniformly and equally distributed throughout the viral genome