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Although efficacy for anti-TNF agents has been proven, up to 30% of patients have no clinical improvement after initiation of anti-TNF therapy (primary nonresponse), and up to 50% of patients lose response over time (secondary nonresponse) [173]

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BPC-157, sometimes called body protection compound, is a peptide studied primarily for its role in tissue repair, gut lining protection, and anti-inflammatory signaling rather than fat metabolism

Food Chem 131:422426 Dons F, Sessa M, Mediouni H, Mgaidi A, Ferrari G (2011) Encapsulation of bioactive compounds in nanoemulsion-based delivery systems

Together with human AKAP11 KO iNeuron, we conducted quantitative mass spectrometry-based proteomics (Tandem Mass Tag (TMT) and Data-independent Acquisition (DIA)) 20,21,22 and analyzed the changes of proteins and cellular pathways in neurons from mutant mouse brains and iNeurons compared to control neurons