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While essential for some physiological processes, an imbalance between free radical production and the bodys ability to manage these reactive species leads to oxidative stress

This process is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways

Although a mitochondrial disorder, LHON shares a final common pathway as in other neurodegenerative disorders, namely (RGC-specific) neuronal degeneration and disrupted axonal transport

B.de AlmeidaA

The likelihood of being tumor-free five years after treatment with 5% 5-FU was 70.0%, with MAL-PDT was 62.7% and 80.5% for imiquimod