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The product of histone methylation reactions, SAH, is an HMT inhibitor due to its affinity with the catalytic site of HMTs that is equal to or greater than SAM, and SAM/SAH ratios are used as an indicator of methylation activity in cells [68,69,70]

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To investigate on this postulation, we have examined the effects of cisplatin on the cellular total GSH level of three tumor (HePG2, A549, SKOV3) and normal (LLCPK1, CHO, GHF1) cell lines