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Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial

Calcium homeostasis abnormalities can lead to mitochondrial malfunction, oxidative stress, and cytotoxicity [121]

As such, BSEP inhibition may not be sufficient for predicting the DILI potential of a drug but rather a contributing factor, and collected data from transporter inhibition may be more accurate [10]