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Skeptics counter that those figures come from voluntary reporting rather than controlled trials, and that questions remain about immunogenicity, whether the body mounts an immune response to the peptide

Abstract D-dimer, a soluble fibrin degradation product that originates from plasmin-induced degradation of cross-linked fibrin, is an important biomarker of coagulation activation and secondary fibrinolysis that is routinely used to rule out venous thromboembolism (VTE), and to evaluate the risk of VTE recurrence, as well as the optimal duration of anticoagulant therapy