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When energy is abundant, citrate is exported from mitochondria through the mitochondrial citrate carrier and cleaved by ATP citrate lyase to generate acetyl-CoA, which is then converted by acetyl-CoA carboxylase into malonyl-CoA, the first committed intermediate in fatty acid biosynthesis ( Once inside the cell, FFAs are bound by fatty acid-binding proteins (FABPs), which facilitate their distribution to distinct intracellular compartments and metabolic pathways ( These early steps in fatty acid handling have important consequences for macrophage function

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4C), indicating that the mitochondrial localization of SLC1A5_var was not disrupted by the treatment

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