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The progressive degeneration of neuronal cells that accompanies the decline of memory and other cognitive functions in subjects with Alzheimers disease is associated with an intracellular aggregation of Tau fibrils, an extra-neuronal accumulation of b-amyloid peptides into senile plaques, and an oxidation-reduction (redox) imbalance of complex etiology

Furman, J

Martn M, Macas M, Escames G et al (2000a) Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress

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Specifically, lower testosterone levels were associated with greater predicted hazard beginning at age 80, an effect that grew wider thereafter (Fig