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5 Materials Reduced glutathione (GSH), oxidized glutathione (GSSG), 1-chloro-2,4-dinitrobenzene (CDNB), dithiotreitol (DTT), chemicals for Lowry solutions, S -hexylglutathione sepharose 6B, tert -butyl hydroperoxide (t-BOOH), EDTA, N -ethylmaleimide, 4-chloro-7-nitrobenzofurazan, 6-mercapto-1-hexanol, 3-bromopyruvate, bovine serum albumin (BSA) and all other reagents were purchased from Sigma-Aldrich (St

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Cellular Repair : Glutathione is involved in the repair of damaged cells, promoting overall health

Treating mice with acivicin, which enhances antioxidant capacity by inhibiting glutathione breakdown, reduced oxidative damage and neurodegeneration even 80 days post-disease onset, highlighting the therapeutic potential of targeting ROS production ( Liu and colleagues used a cuprizone-induced demyelination model in adult male mice to investigate Hv1 in demyelination ( Wang and colleagues further investigated Hv1 in microglial migration and myelin debris clearance ( in vivo , however, the ability of the reported anti-Hv1 antibody to block proton channel activity warrants further investigation