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The induction of angiogenesis in the CNS has been reported to promote pathological conditions such as brain tumor growth, and sterile-venous malformations (SVM) (Vallon and Chang 2014)

Antioxidants 12(11):1999 Zgorzynska E, Dziedzic B, Walczewska A, MDPI (2021) An overview of the Nrf2/ARE pathway and its role in neurodegenerative diseases