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Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]

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This combined exposure can lead to oxidative stress in the intestinal epithelium, barrier damage, and exacerbated inflammatory responses [28]

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doi: 10.1186/1740-2557-2-5 517 MaesMMihaylovaILeunisJC

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