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The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

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For meningeal leukemia, the usual doses are as follows: children younger than 1 year old: 6mg intrathecally children who are 1 year old: 8mg intrathecally children who are 2 years old: 10mg intrathecally children who are 3-8 years old: 10mg intrathecally children over 9 years old: 12-15mg intrathecally For non-Hodgkin lymphoma (induction treatment / multidrug chemo regimen), the usual dose is 1000mg/m per dose IV, given on a specific day of the cycle per regimen

NAD+ and longevity stacks Given that 5-amino-1mq works by preserving NAD+ levels, combining it with direct NAD+ precursors like NMN or NR makes mechanistic sense