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This axis regulates the gut microbiota and brain function bidirectionally through neural anatomical pathways, neuroimmune and neuroendocrine routes, the intestinal mucosal barrier, microbial metabolites, and the blood-brain barrier

2021 May 14;3(3)

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IL-1 in osteoarthritis: time for a critical review of the literature

109 used a brush functionalization technique to create a gradient of TGF-3, decreasing in concentration from the articulating surface to the subchondral region, and likewise created a reverse gradient of BMP-2