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Immunosuppressants (in high dosage) and non-steroidal analgetics are effective only in pre-treatment or post-treatment respectively

Adverse Reactions / Side Effects Common (usually mild and self-limited): Flushing Headache Fatigue Nausea Metallic taste Injection-site pain (IV or IM) Rash or pruritus Moderate: Hypotension during IV infusion Diarrhea Dizziness Transient increases in liver enzymes Allergic reactions (urticaria) Serious (require immediate discontinuation): A

Poor Sleep Quality Low glutathione levels may affect sleep patterns, leading to insomnia or unrestful sleep

Significant differences between the two formulations were observed on days 5 and 7 ( p 0.0036), with a maximum circulatory B12 concentration of 454 3.9 pg/mL measured in the Sucrosomial B12 group compared to 274 11.1 pg/mL in the conventional Mecogen SL B12 group on day 5 (Figure 3 boxplots, bottom)

The compound has not progressed through a drug-approval pathway in any major jurisdiction