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Notably, researchers observed that the rise in p21 levels, a marker of senescence, was independent of p53, indicating that, unlike many previous drugs, AKI603-induced senescence may operate independently of p53 activity [79]

our skin starts to produce less cholesterol with age

Increasing muscle carnitine content alters muscle fuel metabolism and improves exercise performance in humans

Similarly, a model of acute pancreatitis displayed activated microglia, indicating crosstalk between the periphery and parenchymal microglial across BBB (Cabral-Frana et al., 2024)