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In their bioinformatics analysis of the Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma (HNSCC), Yang et al

67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes

These microbial BA metabolites, acting as critical signaling integrators, engage a network of host receptors (including FXR, TGR5, VDR, and S1PR2) expressed on immune cells, cancer cells, and stromal cells

Front Oncol 13:1108564 Acknowledgements This research was supported by the Intramural Research Program of the National Institutes of Health (NIH)

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