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What follows pulls together what the animal literature documents at specific time points, what community protocols report across the standard 10-day on / 4-week off pattern, and where the two sources agree or diverge

In human studies, older individuals with a history of circadian disruption are more likely to develop cataracts, suggesting a cumulative effect of misalignment on lens opacity over time (Yan and Wang, 2016

Auditory sensitivity of northern fur seals (Callorhinus ursinus) and a California sea lion (Zalophus californianus) to airborne sound

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Moreover, in vivo transcellular extrusion of mitochondria from retinal ganglion cells for degradation by neighboring cells is reminiscent of exopher-like biology, and transcellular extrusion and degradation is increased in AD-model mouse brain 62 and has been reported in human neurodegenerative disease brain