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FSN achieved mechanistic module convergence via HDAC/NF-B inhibitors (TSA/PDTC) on top of an ABX + FMT + Butyrate rescue closed loop ( in vivo and within the microbial causal framework to strengthen the necessity inference and test the relative contribution of butyrate to the formulas holistic effect ( 5 Mechanistic module integration: pharmacological chains of TCM/natural products against RA mediated by gut microbiota-derived metabolites A significant challenge in synthesizing the current evidence lies in the methodological heterogeneity across the included studies

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To prepare the sucrose solution and water, approximately 40 mL of water should be added to a 50 mL centrifuge tube, which is then sealed with a straw cap

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doi: 10.1038/s41467-017-02074-2