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Further, in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice, SF treatment (56.4 mol/kg/day for 10 days) attenuated dopaminergic neurotoxicity by activating BDNF and suppressing methyl CpG-binding protein 2 (MeCP2) (84) and activated Nrf2 (1 M SF) (85)