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By improving liver function and fat transport, and supporting energy production through B12, they can make an active, calorie-controlled lifestyle more effective

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

This means that patients can achieve their weight loss goals without experiencing the unwanted effects often associated with hormone-based therapies

Authorship All the authors have made substantial contribution to the preparation of this manuscript

(2007) investigated tesamorelin in a randomized clinical trial and demonstrated its ability to stimulate endogenous GH secretion and modulate visceral adipose tissue parameters, establishing the clinical profile of this blend component [1]