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In the past 10 years, results from several randomized controlled trials (RCTs) have increased the understanding of the role of expectorant/antioxidant therapy in COPD

In mouse models, pharmacological inhibition or genetic deletion of NE reduced cancer progression (78, 180)

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With NACs ability to make and replenish this antioxidant, it helps prevent cellular damage, decrease inflammation, and decrease oxidative stress

Particularly, the activation of adaptive stress response pathways by AQ-QI and DEAQ-QI was elucidated using high-content imaging-based BAC-GFP toxicity assays