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The 48-week extension trial (TIPO-4) demonstrated sustained efficacy, with participants maintaining a total mean weight loss of 13-14kg over the extended treatment period, confirming long-term effectiveness without significant tolerance development

Specifically, we finalized a policy to discontinue the requirement that a code combination (that qualifies for a complexity adjustment by satisfying the frequency and cost criteria thresholds described above) also not create a 2 times rule violation in the higher level or receiving APC

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Interestingly, research shows elevated B12 concentrations in the liver can be a sign of liver damage, but extra vitamin B12 is unlikely to cause liver damage in healthy individuals, notes LiverTox