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However, symptoms may appear even below 350 pg per mL in some individuals

A systematic division of different strategies to target -syn thus separates stabilizing the physiological conformation of -syn, decreasing its expression, inhibiting its aggregation, and increasing intracellular clearance, from transmission-directed approaches including inhibiting uptake by neighboring cells and enhancing extracellular clearance mechanisms (Figure 2

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For instance, oxidized glutathione (GSSG) has recently been shown to suppress the expression of the NDM-1 metallo--lactamase gene, thereby restoring carbapenem susceptibility in E