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The catalytic mechanism of GSTZs differs from other GSTs in that GSH is initially conjugated to the cis double bond of maleylacetoacetate allowing the isomerisation reaction, before being eliminated in a second step allowing the formation of fumarylacetoacetate (Thom et al., 2001)

Hypotheses 143, 110122

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In addition, the BBB poses a significant challenge to the successful implementation of immunotherapy for stroke due to its highly selective nature

This article explains how it actually works, what it realistically achieves on its own, and critically why it produces significantly faster and more lasting results when combined with laser toning or chemical peels