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Patients with elevated Phase I cytochrome P450-enzyme activity should be treated with antioxidant therapy before detoxification begins to slow the production of, and mitigate the damage from, highly toxic biotransformed intermediate molecules that increase oxidative stress on the body

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For instance, resveratrol blocks the AP-1 pathway associated with NF-B inhibition, and simultaneous inhibition of both routes has a common effect on reducing inflammatory factors and alleviating radiation-induced inflammation 37

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L., Heij, L., Vogels, O., van Velzen, M., Sarton, E., Niesters, M., Tannemaat, M