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Together, our data suggest that secondary sulfonylurea failure may reflect islet cell reprogramming and loss of -cell identity, rather than simple -cell exhaustion To view or add a comment, sign in Clinical Efficacy of Second-Generation Tetracyclines as First-Line Systemic Agents for Gingival Lichen Planus In a recent JDD report of 254 biopsyconfirmed patients whose erythematous or erosive gingival oral lichen planus failed topical therapy, a 2month course of doxycycline or minocycline (100 mg twice daily), given alongside topical agents, produced clinical improvement in about 61% of patients

132 However, another meta-analysis that included six randomized controlled trials with a total of 351 participants found that although chromium supplementation decreased insulin resistance it also markedly increased total and free testosterone levels

Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses

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