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This results in the transcriptional upregulation of pro-inflammatory cytokines (IL-1, TNF-, IL-6) [32], chemokines (CXCL8/IL-8, CCL2), antimicrobial peptides, and co-stimulatory molecules that enhance immune cell recruitment and activation [34]

[1] [9] In accordance with human findings, animals exposed to bromantane for extended periods of time do not appear to develop tolerance or dependence

Accidental overdose (taking an over-the-counter acetaminophen-containing product concurrently with a prescription acetaminophen-containing therapy) represents a significant number of acetaminophen toxicities

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