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Addressing this gap in knowledge requires research that takes a longitudinal approach to characterizing trajectories of brain development and depressive symptoms (Gotlib and Ordaz, 2016)

ASC/overlap can be differentiated from typical AIH by a lesser female predisposition, high serum alkaline phosphatase to aspartate aminotransferase (AST) ratio, presence of peri-nuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), stronger association with inflammatory bowel disease (IBD), and a worse prognosis than typical AIH

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7) PXR and Oxidative Stress Responses PXR seems to have mixed effects on oxidative stress [25]

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