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Conversely, the downregulation of sirtuin 6 (SIRT6) in hepatoma cells enables TGF-1/ROS to induce cell senescence, counteracting its tumorigenic effects [112]

[Abstract] Trametinib, a MEK1/2 inhibitor, strongly inhibits growth and partially reverses GW786034 resistance of GW786034-resistant clones.Trametinib-induced inhibition of phosphorylation of ERK1/2 in SS clones is assessed by Western blot analysis with anti-ERK1/2 and anti-phospho-ERK1/2 antibodies

Reduced glutathione (GSH) is a major intracellular antioxidant neutralizing free radicals and detoxifying electrophiles

The following diagram should serve to illustrate this

Arwert LI, Deijen JB, Drent ML