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Other telltale signs of B12 deficiency include: Breathlessness Feeling faint Headaches Pale skin Noticeable heartbeats (palpitations) Hearing sounds coming from inside the body, rather than from an outside source (tinnitus) Loss of appetite and weight loss

While substantial progress has been made in understanding these effects, critical gaps remain in mixture toxicology, low-dose effects, and transgenerational impacts in humans

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MEGALOBLASTIC ANEMIA: DIAGNOSTIC CLUES Macrocytic and megaloblastic anemia from vitamin B 12 deficiency leads to defective DNA synthesis in hematopoietic precursors manifesting as pancytopenia and hemolysis owing to ineffective hematopoiesis