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On the other hand, in cholestatic individuals in whom the NGS panels have not found pathogenic mutations, a comprehensive study like WES, performed over the full exome, can find potential gene candidates for a cholestasis association, as was the case with the most recently discovered PFIC, PFIC 13 [37, 90]

It is, therefore, contraindicated in patients with a history of or active peptic ulcer disease, GI bleeding, or GI perforation

17 A meta-analysis also found reduced glutathione, specifically in the occipital cortex of the brain, in major depression

N., Gazdar, A