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However, C4 levels in IBS-D are not significantly correlated to mucosal permeability as assessed by urinary excretion of lactulose/mannitol, and in 23 patients with IBS-D, treatment with colesevelam tended to improve stool consistency but did not alter mucosal permeability as assessed by lactulose/mannitol excretion (173)

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CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats

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The ROS family produced significantly by oxidative stress can activate Caspase1 and GSDMD, accompanied by the release of a large number of pro-inflammatory factors, thereby inducing cell pyroptosis