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Additional research is recommended

Inhibition of the SSP by small-molecule inhibitors or RNAi targeting core SSP genes reduces xenograft tumour growth (Possemato et al, 2011

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For decades, this rapid enzymatic degradation led many clinicians to believe that oral glutathione supplementation was largely ineffective for raising intracellular levels

This metabolic defect may lead to upregulation of fatty acid -oxidation, needed to maintain mitochondrial membrane potential and ATP production in the context of the FXN deficiency