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Example 9: Coating of size 4 HPMC capsules with a combination of 80% Eudragit NM 30 D and 20% Eudragit L 30 D-55 Preparation of the Eudragit dispersions: The pH of 109 g of Eudragit NM 30 D was adjusted to about 3 with 1.3 ml of a 20% (w/w) citric acid solution

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molecular weight about 1419.5 Da

Primary Endpoint: A Historic HR of 0.17 The primary endpoint of Progression-Free Survival (PFS) demonstrated overwhelming superiority for the immunotherapy combination