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In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity

Two authors independently screened the titles and abstracts, followed by a full-text review of relevant articles to extract key mechanisms and clinical findings discussed in this review

Thrombocytopenia and leukopenia occur regularly with hypersplenism, which may be a presenting or later feature of hepatic WD

Report 213E30F-1, a clinical trial conducted by Bio Basic Europe s.r.l