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Topical serums remain the only mode with reproducible human RCT data

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In flies, slmb targets phosphorylated per for ubiquitin-mediated degradation, a process initiated by dbt-dependent phosphorylation at Ser47 ( Slmb mutants fail to anticipate light-to-dark transitions under light/dark (LD) conditions and display completely arrhythmic behavior under constant darkness (DD), indicating disrupted circadian control ( slmb in Pdf-positive neurons, highlighting its essential role in the clock network (Ko et al., 2002)

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