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The mitochondrial permeability transition pore: an evolving concept critical for cell life and death

10.1016/j.tcm.2004.08.003 142 MorrisonH.ShermanL

However, during the pathological process of RA, the balance of PCD is disturbed and multiple PCD pathways may work together to regulate the onset and progression of RA through complex interaction mechanisms

Other agents exist which also cause damage by a range of processes

Impaired medullary production In IMD, medullary production can be decreased in situations of impaired metabolism of cobalamin and folates (developed in the chapter about megaloblastic anemia) or the accumulation of toxic metabolites impacting the development of hematological stem cells