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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

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Statements Author contributions The manuscript was conceptualized by WH and TC

Glutathione peroxidase levels notably decreased in all groups compared to the control, while peroxynitrite levels also significantly decreased across all groups