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However, the inherent challenges of traditional animal-derived EVssuch as heterogeneity, scalability issues, and ethical concernshave driven researchers to explore more sustainable and safer alternativesPlant-derived extracellular vesicles (PDEVs) (Lian et al., 2022

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The present case series demonstrated that mesotherapy using a combination of Vitamin C, glutathione, and TA is a novel, safe, effective, and minimally invasive approach for gingival melanin depigmentation