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Description

Chronic inflammation may interact with skeletal muscle iron overload, aggravating muscle atrophy

These platelet granules are activated by calcium (Ca2+) and thrombin, which is a protein found circulating in the blood stream

Schuliga M, Chouchane S, Snow ET

Ickowicz S, McLean M

Within this framework, iron accumulation may signal heightened susceptibility to ferroptosis, reflecting defective iron mobilisation and organellar crosstalk rather than simply a reservoir of pro-oxidant potential