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Ruocco MR, Avagliano A, Granato G, Vigliar E, Masone S, Montagnani S et al (2019) Metabolic flexibility in melanoma: a potential therapeutic target

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Studies have demonstrated that ferroptosis inducers such as Erastin and RSL3 significantly enhance the sensitivity of GC cells to cisplatin, offering a promising approach for overcoming chemoresistance (115)

Conclusions and prospects Mitochondria are central organelles responsible for energy metabolism, ROS generation, and the regulation of apoptosis, and their functional abnormalities can drive metabolic reprogramming, promote malignant phenotypes, and shape the immune microenvironment

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