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For example, in reproductive-aged women, pain thresholds are lowest when estrogen drops after ovulation, but are also decreased at the mid-cycle peak in estrogen levels

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Limited Human Data: Very few human clinical trials exist, and those that do are generally small-scale, preliminary investigations

Therefore, we aimed to assess the use of high-dose hydroxocobalamin within our unit as rescue therapy for post-cardiotomy refractory vasoplegic shock and to compare this experience with the existing international data