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No trial reported on clinical signs and symptoms of vitamin B 12 deficiency, health-related quality of life, or acceptability of the treatment scheme Orally taken vitamin B 12 showed lower treatment-associated costs than intramuscular vitamin B 12 in one trial

Patients may need multiple services to reach improved results

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Expected timeline: Week 1-4: Inflammation reduction, potential nerve symptom improvement Week 4-8: Progressive healing, reduced radicular symptoms Week 8-12: Structural improvements developing, continued symptom reduction Week 12-16: Consolidation of gains, assessment for continued protocol Important notes: Disc herniations vary enormously in severity