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doi: 10.1146/annurev-biochem-060713-035504 36

This milieu actively suppresses NPPC function, leading to diminished proliferative and differentiation capacities, loss of stemness markers, and a fate skewed towards cell death or senescence [36, 60]

Its high receptor affinity and resistance to enzymatic degradation make it useful in studies focusing on pituitary modulation, endocrine response, and peptide-receptor communication

To assess the quality and strength of evidence supporting NAC's clinical use in various contexts (e.g., acetaminophen toxicity, chronic obstructive pulmonary disease), the American Family Physician (AFP) Evidence-Based Medicine Toolkit was employed [5]